Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride

Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation hydrochloride. In this present work, direct compression was technique used for preparing using superdisintegrants like croscarmellose sodium, sodium starch glycolate crospovidone at different concentrations. Prepared formulations were evaluated various quality parameters- angle repose, Carr’s index, Hausner ratio, weight variation, friability, hardness, drug content, dispersion time, wetting time in-vitro dissolution. The repose data indicated that flow property all good excellent. Comparing with specifications, results Carr's index (%) Hausner’s ratio flowability blend significantly good. showed average ranging from 40-45 seconds, 3-6 minutes. In-vitro dissolution profile cumulative % release between 30-80% most cases.
 Keywords: Orally tablets, Tramadol hydrochloride, Superdisintegrants, Direct compression.